The Flowers grew up in a musical family in the San Francisco Bay Area, and prior to recording on their own, did a couple of garage-psychedelic singles as part of Crystal Fountain; Wendy sang lead, and Bonnie played drums. Jazz star Cal Tjader put them to the attention of a jazz label he recorded for, Skye, which made the Wendy & Bonnie LP its lone venture into rock. Genesis was pretty sparsely produced, the arrangements highlighting their harmonies and pensive paisley tunes, but did benefit from backing by some top Los Angeles session musicians, including drummer Jim Keltner and guitarist Larry Carlton.

The album was released in 1969, but stalled when Skye Records folded the following year. The death of producer Gary McFarland in 1971 further discouraged the duo. Although they did sing backup vocals on a couple of Tjader albums and some jingles and background vocals at Fantasy Records, they never recorded their own material again, and broke up in the early '70s. They did perform music separately in the subsequent decades, Wendy Flower issuing a children's music cassette, and Bonnie Flower once rejecting an invitation to join the Bangles. The rare Genesis album was reissued with bonus tracks by Sundazed in 2001.