In addition to fronting Material, Laswell also mounted a solo career, issuing Baselines in 1982 on Celluloid, a label he partly owned and operated. Appearances on key recordings by the likes of David Byrne, John Zorn, Fred Frith, and the Golden Palominos established Laswell as a virtual nexus of the downtown N.Y.C. community, and in 1983 he broke into the mainstream with his production work on Herbie Hancock's smash "Rockit," which he also co-wrote; the follow-up LP, Sound-System, won him a Grammy. Throughout the mid-'80s Laswell was everywhere, playing bass on LPs from artists including Mick Jagger, Peter Gabriel, Yoko Ono, and Laurie Anderson; he also joined the avant group Curlew, and produced a number of African acts.

In 1986, Laswell joined guitarist Sonny Sharrock, drummer Ronald Shannon Jackson, and saxophonist Peter Brötzmann in the group Last Exit; a second solo LP, Hear No Evil, appeared two years later, and after a long hiatus he also resurrected Material in 1989 with Seven Souls. Another project, the hip-hop-flavored Praxis, was resumed after close to a decade of inactivity with 1992's Transmutation (Mutatis Mutandis). In 1990, Laswell formed another label, Axiom, to explore his interest in the new sounds of ambient and techno; where in the past his work rarely appeared solely under his own name, by the middle of the decade he was issuing several solo records annually in a wide range of styles from dub to jazz. He also remained among the most prolific producers in the business, collaborating with the likes of Dub Syndicate, Pete Namlook, Buckethead, and DJ Spooky.

In 2004, Laswell signed a multi-album label deal with the Sanctuary Records group. The deal spawned his new label, Nagual. He also began to collaborate on a series of drum'n'bass-styled recordings with Submerged (aka Kurt Gluck of the Ohm Resistance imprint), the first of these -- attributed to Bill Laswell vs. Submerged -- was entitled Brutal Calling and issued by Avant in 2004 with contributions from Toshinori Kondo and Guy Licata. Through the Sanctuary label's earlier acquisition of the seminal reggae label Trojan, Laswell now had access to the Jamaican label's sizable back catalog. Picking some of his favorite cuts and remixing them, Laswell issued the Trojan-sourced Dub Massive: Chapter One and Chapter Two in May 2005. The Only Way to Go Is Down followed on Sublight Records in 2006.

Laswell and Submerged re-teamed under the Method of Defiance moniker for 2007's Inamorata, on Ohm Resistance. This date found the pair teaming various drum'n'bass producers -- Amit, Paradox, Submerged, Future Prophecies, Karsh Kale, Evol Intent, SPL, Outrage, Fanu, and Corrupt Souls -- with jazz, rock, and avant artists such as Herbie Hancock, John Zorn, Pharoah Sanders, Nils Petter Molvaer, Kondo, and Buckethead. Laswell (as Method of Defiance) also released a collaboration with Finnish producer Fanu on Ohm Resistance entitled Lodge, which includes contributions from Molvaer and Bernie Worrell. The notion of a live band created around the Method of Defiance structure was initiated with participation from Laswell, Worrell, Kondo, Licata, and Dr. Israel. The group was documented on Nihon from the RareNoise imprint in 2009.

In 2010, Laswell initiated a new label called M.O.D. Technologies. Said to be centered around the principles of a solidified Method of Defiance lineup, the label released three albums: Method of Defiance's Jahbulon (a reggae album featuring Hawk and Dr. Israel), the instrumental dub-centric Incunabula, and a live offering from Laswell's spouse, Gigi, with Material, entitled Mesgana Ethiopia. Laswell collaborated with master reggae and Radical Jewish Culture bassist/composer David Gould on a dub version of the latter's 2009 album Feast of the Passover. The new recording, entitled Dub of the Passover, was issued by Tzadik in 2011. Metastation released Aspiration, an electronic album billed to Bill Laswell & Friends (including Alice Coltrane, Carlos Santana, Pharoah Sanders, and Zakir Hussain) -- the tunes were dedicated to the ensemble members' own inspirational figures, including H.H. Dalai Lama XIV, Sonny Sharrock, Rumi, and Pattabhi Jois.